19 December 2015

Moms' high-fat, sugary diets up offspring's risk of drug, alcohol abuse

High-fat and high-sugar foods a mother eats during pregnancy are likely to put her baby at risk for drug and alcohol problems later in life, U.S. researchers said Saturday.

In animal experiments, the offspring of rats that ate high-fat or high-sugar diets while pregnant weighed more as adults and drank more alcohol, and those on high-sugar diets also had stronger responses to commonly abused drugs such as amphetamine, when compared with pups of rats that ate "regular rodent chow."

"The majority of women in the U.S. at child-bearing age are overweight, and this is most likely due to overeating the tasty, high-fat, high-sugar foods you find everywhere in our society," Nicole Avena, a research neuroscientist at the University of Florida, said in a statement.

"The rise in prenatal and childhood obesity and the rise in number of youths abusing alcohol and drugs merits looking into all the possible roots of these growing problems," she said.

Avena presented her findings at the American Psychological Association's 121st annual meeting this week, held in Honolulu, Hawaii.

The researchers compared weight and drug-taking behavior between the offspring of rats fed diets rich in fats, sucrose or high-fructose corn syrup with the offspring of rats fed regular rodent chow during gestation or nursing in three studies, each lasting about three months and involving three to four adult female rats and 10 to 12 offspring in each dietary condition.

They tested both sucrose and high-fructose corn syrup because they are chemically different and could cause different outcomes, Avena said. Sucrose occurs naturally and is commonly processed from sugar cane or sugar beets into table sugar, whereas high- fructose corn syrup is synthesized from corn.

The offspring of rats that had high-fat diets while pregnant drank significantly more alcohol in adulthood than the offspring of rats with the regular chow diet. They also had significantly higher levels of triglycerides, a type of fat found in the bloodstream that can increase the risk of heart disease.

To test the effects of diets high in sucrose and high-fructose corn syrup, researchers gave one group of the pregnant rats a daily diet of regular chow plus a 10 percent sucrose solution or a 16 percent high-fructose corn syrup solution.

Pups nursed by rats with either high-sucrose or the high- fructose corn syrup diets while pregnant drank more alcohol compared to offspring born to the group that did not have sugar.

Further, pups exposed to either of the sugar-rich diets before birth or during nursing became hyperactive when given low doses of amphetamine, suggesting sensitivity to the drug. These animals also weighed significantly more at the end of the study than those born to the rats that ate regular chow.

Previous research with lab animals and people has shown that overeating foods that taste good alters brain reward systems, and diets with excessive fat and sugar can lead to increased appetite as well as some addiction-like behaviors.

"Our findings suggest that even while rats are still in the womb, exposure to high-fat and sugar-rich diets can, in addition to increasing body weight, lead to a predisposition to drink alcohol and a sensitivity to drugs," Avena said.